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A few of your individuals experienced no detectable serum concentrations of metronidazole at any time point. The signify dose of gel used all through clinical experiments was 600 mg which represents 4.5 mg of metronidazole for each software. As a result, under standard use amounts, the formulation affords nominal serum concentrations of metronidazole. The mechanisms by which METROGEL® (metron-idazole topical gel) Topical Gel acts within the treatment of rosacea are mysterious, but appear to incorporate an anti-inflammatory result.

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The appearance of irregular neurologic indications requires the prompt discontinuation of metronidazole vaginal gel therapy. Metronidazole vaginal gel ought to be administered with warning to sufferers with central anxious technique disorders.

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Fertility scientific studies have already been done in mice up to 6 occasions the advisable human oral dose (depending on mg/m²) and have unveiled no proof of impaired fertility.

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